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The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells

GSE263112 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/27 Platform GPL23227
Summary
The receptor-interacting protein kinase 4 (RIPK4) plays an oncogenic role in melanoma by regulating NFκB and Wnt/β-catenin pathways. As its role in melanoma remains not fully understood, we examined the effects of its downregulation on melanoma transcriptomics. Using RNA-seq, we observed broad transcriptome changes in WM266.4 cells upon RIPK4 downregulation, indicating a complex role for RIPK4 in regulating adhesion, migration, proliferation, and inflammatory processes in melanoma cells. Furthermore, our study highlights the potential functional partners of RIPK4, such as BIRC3, TNF-α receptors, and MAP2K6.
Published in
The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells
Madej E, Lisek A, Brożyna AA et al. · Journal of cancer research and clinical oncology 2024 · PMID 38656555 · doi:10.1007/s00432-024-05732-3
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Also filed as BioProject PRJNA1095880 and SRA study SRP499524. Searching any of these in the dataset finder brings you back here.

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