Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation
RNA-seq (gene expression) · human · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 23 samples: 8 × Human-Patient-Sample vs 5 × Naive_RiboTag IP vs 5 × IM3h_RiboTag IP vs 5 × IM24h_RiboTag IPGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammationEMBO molecular medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263125_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1095896 and SRA study SRP499564. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 5 as controls.
How we read this: 4 replicated groups read from 23 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8186177 Human-Patient-Sample 1 Human-Patient-Sample
- GSM8186178 Human-Patient-Sample 2 Human-Patient-Sample
- GSM8186179 Human-Patient-Sample 3 Human-Patient-Sample
- GSM8186180 Human-Patient-Sample 4 Human-Patient-Sample
- GSM8186181 Human-Patient-Sample 5 Human-Patient-Sample
- GSM8186182 Human-Patient-Sample 6 Human-Patient-Sample
- GSM8186183 Human-Patient-Sample 7 Human-Patient-Sample
- GSM8186184 Human-Patient-Sample 8 Human-Patient-Sample
- GSM8186185 Naive_RiboTag IP_1 Naive_RiboTag IP
- GSM8186186 Naive_RiboTag IP_2 Naive_RiboTag IP
- GSM8186187 Naive_RiboTag IP_3 Naive_RiboTag IP
- GSM8186188 Naive_RiboTag IP_4 Naive_RiboTag IP
- GSM8186189 Naive_RiboTag IP_5 Naive_RiboTag IP
- GSM8186190 IM3h_RiboTag IP_1 IM3h_RiboTag IP
- GSM8186191 IM3h_RiboTag IP_2 IM3h_RiboTag IP
- GSM8186192 IM3h_RiboTag IP_3 IM3h_RiboTag IP
- GSM8186193 IM3h_RiboTag IP_4 IM3h_RiboTag IP
- GSM8186194 IM3h_RiboTag IP_5 IM3h_RiboTag IP
- GSM8186195 IM24h_RiboTag IP_1 IM24h_RiboTag IP
- GSM8186196 IM24h_RiboTag IP_2 IM24h_RiboTag IP
- GSM8186197 IM24h_RiboTag IP_3 IM24h_RiboTag IP
- GSM8186198 IM24h_RiboTag IP_4 IM24h_RiboTag IP
- GSM8186199 IM24h_RiboTag IP_5 IM24h_RiboTag IP
- GSE243750 SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE 288 samples shares impairment
- GSE327210 Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene Smarcc2 and its Rescue by Histone Deacetylase Inhibition 16 samples shares impairment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.