SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes : Gene expression 1
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263260_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1067725 and SRA study SRP485278. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8188746 RNA_Skp1aKO9.5dpc_mblot1 RNA_Skp1aKO9.5dpc_mblot
- GSM8188747 RNA_Skp1aKO9.5dpc_mblot2 RNA_Skp1aKO9.5dpc_mblot
- GSM8188748 RNA_wt9.5dpc_mblot1 RNA_wt9.5dpc_mblot
- GSM8188749 RNA_wt9.5dpc_mblot2 RNA_wt9.5dpc_mblot
- GSM8188750 RNA_Skp1acont9.5dpcPI_mblot1 RNA_Skp1acont9.5dpcPI_m…
- GSM8188751 RNA_Skp1acont9.5dpcPI_mblot2 RNA_Skp1acont9.5dpcPI_m…
- GSM8188752 RNA_Skp1acont9.5dpc_mblot1 RNA_Skp1acont9.5dpc_mbl…
- GSM8188753 RNA_Skp1acont9.5dpc_mblot2 RNA_Skp1acont9.5dpc_mbl…
- GSM8188754 RNA_wt9.0dpc_mblot1 RNA_wt9.0dpc_mblot
- GSM8188755 RNA_wt9.0dpc_mblot2 RNA_wt9.0dpc_mblot
- GSM8188756 RNA_wt9.5dpcPI_mblot1 RNA_wt9.5dpcPI_mblot
- GSM8188757 RNA_wt9.5dpcPI_mblot2 RNA_wt9.5dpcPI_mblot
- GSE293160 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [RNA-seq] 24 samples shares prc2, polycomb-silenced, skp1a-mediated, degradation, activation, triggers
- GSE263263 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes : CUT&Tag 1 20 samples shares prc2, polycomb-silenced, skp1a-mediated, degradation, activation, triggers
- GSE297309 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [CUT&Tag] 108 samples shares prc2, polycomb-silenced, skp1a-mediated, degradation, activation, triggers
- GSE263265 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes : CUT&Tag 2 12 samples shares prc2, polycomb-silenced, skp1a-mediated, degradation, activation, triggers
- GSE297094 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [ChIP-seq 2] 73 samples shares prc2, polycomb-silenced, skp1a-mediated, degradation, activation, triggers
- GSE293161 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [ChIP-seq] 16 samples shares prc2, polycomb-silenced, skp1a-mediated, degradation, activation, triggers
- GSE219083 G-quadruplex folding in Xist RNA antagonizes PRC2 activity for step-wise regulation of X-chromosome inactivation 36 samples shares prc2, activation
- GSE305084 Oncogenic Ras drives EED degradation and PRC2 dysfunction to promote aggressive squamous cell carcinoma [mouse CUT & RUN] 12 samples shares prc2, degradation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.