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Targeting RBM39 for Improved Outcomes as a Novel Therapeutic Strategy in T-cell acute lymphoblastic leukemia

GSE263309 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/08/02 Platform GPL24676
Summary
Indisulam demonstrates significant antineoplastic properties in the context of T-cell acute lymphoblastic leukemia (T-ALL). Its effectiveness is primarily due to the degradation of RBM39, attenuating cell proliferation, promoting apoptosis and interfering with cell cycle progression in vitro, while facilitating tumor remission in T-ALL in vivo models.
Published in
Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia
Ji T, Yang Y, Yu J et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 39044280 · doi:10.1186/s13046-024-03130-8
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Also filed as BioProject PRJNA1096684 and SRA study SRP499957. Searching any of these in the dataset finder brings you back here.

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