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Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus

GSE263365 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/04/10 Platform GPL18573
Summary
Inflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the disease, the development of islet inflammation remains unclear. Here, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment. We identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types. Overall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and activation, which are key steps in the pathophysiology of diabetes mellitus.
Published in
Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus
Muñoz García A, Juksar J, Groen N et al. · Frontiers in immunology 2024 · PMID 38742118 · doi:10.3389/fimmu.2024.1381319
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Also filed as BioProject PRJNA1096823 and SRA study SRP500004. Searching any of these in the dataset finder brings you back here.

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