CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells [PAC-seq]
RNA-seq (gene expression) · human · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 27 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cellsCell reports · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263384_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1097250 and SRA study SRP500161. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 9 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8190643 LNCaP CTRL sh BR1 LNCaP CTRL sh B
- GSM8190644 LNCaP CPSF1 sh1 BR1 LNCaP CPSF1 sh1 B
- GSM8190645 LNCaP CPSF1 sh2 BR1 LNCaP CPSF1 sh2 B
- GSM8190646 LNCaP CTRL sh BR2 LNCaP CTRL sh B
- GSM8190647 LNCaP CPSF1 sh1 BR2 LNCaP CPSF1 sh1 B
- GSM8190648 LNCaP CPSF1 sh2 BR2 LNCaP CPSF1 sh2 B
- GSM8190649 LNCaP CTRL sh BR3 LNCaP CTRL sh B
- GSM8190650 LNCaP CPSF1 sh1 BR3 LNCaP CPSF1 sh1 B
- GSM8190651 LNCaP CPSF1 sh2 BR3 LNCaP CPSF1 sh2 B
- GSM8190652 LNCaP95 CTRL sh BR1 LNCaP95 CTRL sh B
- GSM8190653 LNCaP95 CPSF1 sh1 BR1 LNCaP95 CPSF1 sh1 B
- GSM8190654 LNCaP95 CPSF1 sh2 BR1 LNCaP95 CPSF1 sh2 B
- GSM8190655 LNCaP95 CTRL sh BR2 LNCaP95 CTRL sh B
- GSM8190656 LNCaP95 CPSF1 sh1 BR2 LNCaP95 CPSF1 sh1 B
- GSM8190657 LNCaP95 CPSF1 sh2 BR2 LNCaP95 CPSF1 sh2 B
- GSM8190658 LNCaP95 CTRL sh BR3 LNCaP95 CTRL sh B
- GSM8190659 LNCaP95 CPSF1 sh1 BR3 LNCaP95 CPSF1 sh1 B
- GSM8190660 LNCaP95 CPSF1 sh2 BR3 LNCaP95 CPSF1 sh2 B
- GSM8190661 22Rv1 CTRL sh BR1 22Rv1 CTRL sh B
- GSM8190662 22Rv1 CPSF1 sh1 BR1 22Rv1 CPSF1 sh1 B
- GSM8190663 22Rv1 CPSF1 sh2 BR1 22Rv1 CPSF1 sh2 B
- GSM8190664 22Rv1 CTRL sh BR2 22Rv1 CTRL sh B
- GSM8190665 22Rv1 CPSF1 sh1 BR2 22Rv1 CPSF1 sh1 B
- GSM8190666 22Rv1 CPSF1 sh2 BR2 22Rv1 CPSF1 sh2 B
- GSM8190667 22Rv1 CTRL sh BR3 22Rv1 CTRL sh B
- GSM8190668 22Rv1 CPSF1 sh1 BR3 22Rv1 CPSF1 sh1 B
- GSM8190669 22Rv1 CPSF1 sh2 BR3 22Rv1 CPSF1 sh2 B
- GSE245969 EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells 122 samples shares inhibition, prostate
- GSE309034 Combined BET Bromodomain and DNMT Inhibition Targets Lineage Plasticity in Prostate Cancer [BETi_DNMTi_human_RNAseq] 44 samples shares inhibition, prostate
- GSE292828 Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications [scRNA-seq] 39 samples shares inhibition, promotes
- GSE322615 Investigating response to PARP inhibition and androgen receptor pathway inhibition in C4-2B prostate cancer cells 39 samples shares inhibition, prostate
- GSE210746 Characterization of 3′UTRCES-mediated alternative polyadenylation (APA) engineering in prostate cancer and 293FT cells 15 samples shares polyadenylation, prostate
- GSE325471 The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication 12 samples shares inhibition, prostate
- GSE281320 DNMT3B promotes neuroblastoma growth and survival, and its inhibition demonstrates antitumor effects. 6 samples shares inhibition, promotes
- GSE199913 KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage 231 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.