GEO series
Identification of genes regulated by knockdown of EWS-FLI1 in Ewing sarcoma cells.
GSE263504
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/09/30
GPL24676
Summary
EWS-FLI1 is the driver oncogene in >85% of Ewing sarcoma tumors. We used siRNA to knock down EWS-FLI1 for 48h hours in two Ewing sarcoma cell lines (EW8, TC71) to identify downstream genes and pathways affected by loss of EWS-FLI1 activity. RNAseq analysis was performed after 48 hours of treatment with a nontargeting siControl or siEWS-FLI1.
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Paper (PMID 39201282) ↗
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