GEO series
scRNAseq of CD8+ T cells from autoimmune encephalitis
GSE263666
Homo sapiens
Expression profiling by high throughput sequencing
11 samples
2025/08/15
GPL24676
Summary
Single-cell RNA sequencing in seven anti-Ri autoimmune encephalitis (AIE) patients and three controls showed that neuron-reactive CD8+ T cells are cytotoxic KIR+ CD8+ regulatory T cells. In Ri-AIE, these cells had reduced KIR and IKZF2 (Helios) expression, alongside activated TCR signaling and elevated TNF and IFNG. They also overexpressed TOX, linked to brain-infiltrating cytotoxicity. These findings suggest a loss of regulatory function in KIR+ CD8+ T cells contributes to Ri-AIE pathogenesis.
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Paper (PMID 41022795) ↗
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