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Impact of EMT-driven plasticity on phenotypic diversity dynamics under chemotherapy [organoids]

GSE263728 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/04 Platform GPL24676
Summary
Triple negative breast cancer (TNBC) is the most lethal breast cancer subgroup, as lack of targeted therapies and drug resistance reduce survival rates. Cellular plasticity enables cells to adapt non-genetically and overcome therapeutic pressure, thereby embodying a critical clinical hurdle. The epithelial-mesenchymal transition (EMT) is an example of phenotypic reprogramming linked to plasticity, drug resistance and metastasis. However, its exact impact on population diversity under therapeutic pressure is unknown. Here, we used single cell transcriptomics to investigate phenotypic diversity dynamics upon drug treatment in two human in vitro models of TNBC plasticity.
Published in
EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer
Muller L, Fauvet F, Chassot C et al. · Cancer cell international 2025 · PMID 39901189 · doi:10.1186/s12935-025-03637-w
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Also filed as BioProject PRJNA1098863 and SRA study SRP500865. Searching any of these in the dataset finder brings you back here.

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