Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophreniaMolecular psychiatry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263845_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1099596 and SRA study SRP501416. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8200028 Het_AKAP11-KO-Clone 16_ChIP
- GSM8200029 Het_AKAP11-KO-Clone 20_ChIP
- GSM8200030 Het_AKAP11-KO-Clone 21_ChIP
- GSM8200031 WT_SBP009_Rep1_ChIP
- GSM8200032 WT_SBP009_Rep2_ChIP
- GSM8200033 WT_SBP009_Rep3_ChIP
- GSM8200034 Het_AKAP11-KO-Clone 16_Input
- GSM8200035 Het_AKAP11-KO-Clone 20_Input
- GSM8200036 Het_AKAP11-KO-Clone 21_Input
- GSM8200037 WT_SBP009_Input
- GSE263847 Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia [RNA-seq] 6 samples shares akap11, loss-of-function, schizophrenia, consequences, heterozygous, epigenomic, mutations, disorder
- GSE290454 Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [ChIP-Seq] 20 samples shares akap11, heterozygous
- GSE290452 Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [RNA-Seq] 12 samples shares akap11, heterozygous
- GSE262442 Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs 69 samples shares loss-of-function, disorder
- GSE284610 KDM5C and KDM5D mutations have different and opposing consequences in ccRCC cells [RNASeq_double_KO] 27 samples shares consequences, mutations
- GSE278808 Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons 26 samples shares schizophrenia, mutations
- GSE284611 KDM5C and KDM5D mutations have different and opposing consequences in ccRCC cells [RNASeq_single_KO] 16 samples shares consequences, mutations
- GSE290591 Molecular consequences of a PHF21A variant, c.1285G>A, associated with autism spectrum disorder 10 samples shares consequences, disorder
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.