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Effect of knock-down of circular RNA circUCK2 on gene expression in PLC/PRF/5 cell

GSE263915 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/10 Platform GPL24676
Summary
CircRNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular caicinoma(HCC) progression remain insuffuciently elucidated. Here we uncovered a novol circular RNA, circUCK2, which is highly expressed in HCC tissues and associated with recurrence-free survival in HCC patients. Knockdown of circUCK2 inhibits proliferation and metastasis of HCC cell lines.To investigate the function of circUCK2-silence in HCCs, we performed gene expression profiling analysis using data obtained from RNA-seq of PLC/PRF/5 cells.
Published in
CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4-TGFα-EGFR signaling
Wei X, Si A, Zhao S et al. · Cellular & molecular biology letters 2025 · PMID 39885395 · doi:10.1186/s11658-025-00690-1
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Also filed as BioProject PRJNA1099912 and SRA study SRP501618. Searching any of these in the dataset finder brings you back here.

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