← BioTransfer GEO Dataset Finder
GEO series

A correctable immune niche for basal-epithelial stem-cell reprogramming and post-viral lung diseases

GSE263930 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/11 Platform GPL24247
Summary
Epithelial barriers are programmed for defense and repair but are also frequently the site of long-term remodeling disease. In general, this paradigm features activation of epithelial stem cells that coordinate organ development but persist into adult life to regenerate damaged tissues. Here we identify a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functions as an early sentinel niche for basal-epithelial stem cells (basal-ESC) growth and feed-forward inflammation in mouse models of epithelial injury due to respiratory viral infections. This niche function depends on Gpnmb-CD44 signaling so that transient but properly timed antibody blockade of ligand or receptor provides long-lasting disease correction in these injuries. These same control points are found for mouse and human basal-ESC-derived organoids, and the corresponding biomarkers track with comparable lung diseases in humans. Together, the findings identify a mechanism to explain and modify basal-ESC reprogramming in what is otherwise a stereotyped, primordial response to epithelial injury.
Published in
A correctable immune niche for epithelial stem cell reprogramming and post-viral lung diseases
Wu K, Zhang Y, Yin-DeClue H et al. · The Journal of clinical investigation 2024 · PMID 39052353 · doi:10.1172/JCI183092
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE263930_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1100402 and SRA study SRP501723. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.