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Exploring the mechanism of AGR2 regulating the progression of pancreatic ductal adenocarcinoma and remodeling of the tumor microenvironment [CUT&Tag]

GSE264148 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2024/11/26 Platform GPL24676
Summary
Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and lethal malignant tumor characterized by extensive desmoplasia. We found that AGR2 deletion reshapes the tumor microenvironment by affecting the activation of the IGF1 signaling pathway. On the one hand, AGR2, as an endoplasmic reticulum protein, promoted correct folding and cell surface distribution of IGF1R. On the other hand, AGR2 was secreted into the extracellular space, promoting IGF1 transcription by activating the WNT pathway in cancer-associated fibroblasts (CAFs). Through these mechanisms, AGR2 significantly enhanced the IGF1 signal in the PDAC tumor microenvironment, accelerating the formation of desmoplasia and an immunosuppressive microenvironment.
Published in
Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
Li H, Zhang Z, Shi Z et al. · Cell reports. Medicine 2025 · PMID 39914384 · doi:10.1016/j.xcrm.2024.101927
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Also filed as BioProject PRJNA1101058 and SRA study SRP502093. Searching any of these in the dataset finder brings you back here.

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