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Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway

GSE264255 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/08 Platform GPL24676
Summary
In this study, we aimed to investigate whether all available P-CABs exhibit anti-inflammatory effects in gastroesophageal reflux-induced esophagitis and to elucidate the underlying mechanisms. Het-1A cells, normal esophageal epithelial cells, were treated with HCl (pH 4) for 30 min. Esomeprazole, a representative PPI, and three currently marketed P-CABs (vonoprazan, tegoprazan, and fexuprazan) were used for pretreatment. Total RNA sequencing was performed using Het-1A cells pretreated with 1% DMSO or fexuprazan, followed by exposure to HCl.
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Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway
Kim SY, Yoon JH, Jung DH et al. · Frontiers in immunology 2024 · PMID 39737189 · doi:10.3389/fimmu.2024.1410904
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Also filed as BioProject PRJNA1101551 and SRA study SRP502444. Searching any of these in the dataset finder brings you back here.

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