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Menin is a Targetable Epigenetic Regulator in Glioblastoma (RNA-Seq)

GSE264270 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/17 Platform GPL24676
Summary
Glioblastomas (GBM) are highly lethal tumors that are refractory to treatment. Here we describe a novel approach to target the epigenetic landscape of GBM and destabilize the glioma progenitor program, leading to inhibition of tumor growth. This is achieved through disruption of the activities of menin, an orphan protein that we demonstrate to play a pro-oncogenic role in GBM. Using pharmacologic and genetic tools, we identify HMGN1, a nucleosome binding chromatin architectural protein as a novel partner for menin. Disruption of this interaction via a newly designed small molecule mimics the major effects of knocking out MEN1, particularly leading to the suppression of H3K27 acetylation marks at genes critical for glioma progenitor identity, as well as promising therapeutic in vivo activity. This work demonstrates a novel role for menin as an epigenetic co-regulator of maintenance and proliferation of glioma.
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Also filed as BioProject PRJNA1101576 and SRA study SRP502458. Searching any of these in the dataset finder brings you back here.

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