Transcriptome profiling of human myogenic progenitors following treatment with nicotinamide (NAM) or pyridoxine (PN) or the combination (NAM/PN).
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during agingThe Journal of clinical investigation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264285_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1101870 and SRA study SRP502561. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8215491 Donor29_PN
- GSM8215492 Donor29_ComboNAM-PN
- GSM8215493 Donor29_CTRL
- GSM8215494 Donor29_NAM
- GSM8215495 Donor4_PN
- GSM8215496 Donor4_ComboNAM-PN
- GSM8215497 Donor4_CTRL
- GSM8215498 Donor4_NAM
- GSM8215499 Donor512_PN
- GSM8215500 Donor512_ComboNAM-PN
- GSM8215501 Donor512_CTRL
- GSM8215502 Donor512_NAM
- GSM8215503 Donor7_PN
- GSM8215504 Donor7_ComboNAM-PN
- GSM8215505 Donor7_CTRL
- GSM8215506 Donor7_NAM
- GSM8215507 Donor8913_PN
- GSM8215508 Donor8913_ComboNAM-PN
- GSM8215509 Donor8913_CTRL
- GSM8215510 Donor8913_NAM
- GSE261334 Dynamics and single-cell transcriptomics of circulating immune cell populations in inflammatory bowel disease upon anti-integrin treatment 29 samples shares nam, treatment
- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares nam
- GSE264443 Dynamic gene expression analysis reveals distinct severity phases of immune and cellular dysregulation in COVID-19 189 samples shares nam
- GSE319722 Spatial dynamics links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in microsatellite stable colorectal cancer 117 samples shares nam
- GSE289582 Baseline tumor features and peripheral blood immune dynamics that underlie efficacy in MSS metastatic colorectal cancer treated with regorafenib, ipilimumab, and nivolumab [Blood] 115 samples shares nam
- GSE330029 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis [BulkRNAseq] 108 samples shares nam
- GSE315928 Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer [paired scRNA/TCR-seq] 94 samples shares nam
- GSE245175 Neuroblastoma heterogeneity and plasticity over disease progression are rooted in the dynamics of an early sympathetic transcriptional trajectory 79 samples shares nam
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.