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ALKBH5-mediated m6A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis

GSE264515 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/09/13 Platform GPL24676
Summary
Hypertrophic scars (HTS) are fibrotic skin disorders characterized by excessive deposition of dermal extracellular matrix (ECM), presenting significant challenges in clinical management despite incomplete understanding of their underlying mechanisms. Using MeRIP-seq and RNA-seq, our study initially revealed the direct regulatory role of ALKBH5 on ECM components in dermal fibroblasts, thereby involving in the pathogenesis of HTS.
Published in
ALKBH5-mediated m(6)A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis
Xu R, Yang E, Liang H et al. · Clinical and translational medicine 2024 · PMID 39233335 · doi:10.1002/ctm2.70016
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Also filed as BioProject PRJNA1102882 and SRA study SRP503162. Searching any of these in the dataset finder brings you back here.

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