The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia (ATAC-Seq)
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 9 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 3 × NpatKI, dTAG, 0hr, vs 3 × NpatKI, dTAG, 3hr, vs 3 × NpatKI, dTAG, 12hr,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264594_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1103209 and SRA study SRP503402. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8223511 NpatKI, dTAG, 0hr, rep1 NpatKI, dTAG, 0hr,
- GSM8223512 NpatKI, dTAG, 0hr, rep2 NpatKI, dTAG, 0hr,
- GSM8223513 NpatKI, dTAG, 0hr, rep3 NpatKI, dTAG, 0hr,
- GSM8223514 NpatKI, dTAG, 3hr, rep1 NpatKI, dTAG, 3hr,
- GSM8223515 NpatKI, dTAG, 3hr, rep2 NpatKI, dTAG, 3hr,
- GSM8223516 NpatKI, dTAG, 3hr, rep3 NpatKI, dTAG, 3hr,
- GSM8223517 NpatKI, dTAG, 12hr, rep1 NpatKI, dTAG, 12hr,
- GSM8223518 NpatKI, dTAG, 12hr, rep2 NpatKI, dTAG, 12hr,
- GSM8223519 NpatKI, dTAG, 12hr, rep3 NpatKI, dTAG, 12hr,
- GSE264595 The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia (RNA-Seq) 18 samples shares xpo7-npat, vulnerabilities, tp53-mutated, represents, leukemia, myeloid, acute
- GSE313359 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [Cut & Run] 45 samples shares vulnerabilities, acute
- GSE301500 Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers [ATAC-seq] 11 samples shares vulnerabilities, atac-seq
- GSE313357 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [RNA-Seq] 9 samples shares vulnerabilities, acute
- GSE240460 Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia 6 samples shares vulnerabilities, leukemia
- GSE289162 Plasticity of epigenomic aging creates vulnerabilities to early-life environmental exposures, reshaping adult cell- and direction-specific trajectories 54 samples shares vulnerabilities
- GSE301496 Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers [CUT&Run] 20 samples shares vulnerabilities
- GSE334560 MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities 8 samples shares vulnerabilities
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.