DC-SIGN+ Macrophages alleviates Non-Alcoholic Steatohepatitis by modulating inflammatory cytokine secretion
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 4 × Liver AAV-hDC-SIGN-HFHC vs 3 × Liver AAV-CON-NCD vs 3 × Liver AAV-hDC-SIGN-NCD vs 3 × Liver AAV-CON-HFHCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DC-SIGN(+) macrophages alleviate metabolic dysfunction-associated steatotic liver disease via fine-tuning TLR4 signaling and inflammatory secretory profilesMetabolism: clinical and experimental · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264747_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1104132 and SRA study SRP503755. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 4 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8227140 Liver AAV-CON-NCD-1 Liver AAV-CON-NCD
- GSM8227141 Liver AAV-CON-NCD-2 Liver AAV-CON-NCD
- GSM8227142 Liver AAV-CON-NCD-3 Liver AAV-CON-NCD
- GSM8227143 Liver AAV-hDC-SIGN-NCD-1 Liver AAV-hDC-SIGN-NCD
- GSM8227144 Liver AAV-hDC-SIGN-NCD-2 Liver AAV-hDC-SIGN-NCD
- GSM8227145 Liver AAV-hDC-SIGN-NCD-3 Liver AAV-hDC-SIGN-NCD
- GSM8227146 Liver AAV-CON-HFHC-1 Liver AAV-CON-HFHC
- GSM8227147 Liver AAV-CON-HFHC-2 Liver AAV-CON-HFHC
- GSM8227148 Liver AAV-CON-HFHC-3 Liver AAV-CON-HFHC
- GSM8227149 Liver AAV-hDC-SIGN-HFHC-1 Liver AAV-hDC-SIGN-HFHC
- GSM8227150 Liver AAV-hDC-SIGN-HFHC-2 Liver AAV-hDC-SIGN-HFHC
- GSM8227151 Liver AAV-hDC-SIGN-HFHC-3 Liver AAV-hDC-SIGN-HFHC
- GSM8227152 Liver AAV-hDC-SIGN-HFHC-4 Liver AAV-hDC-SIGN-HFHC
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares macrophages, cytokine
- GSE282257 Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages 40 samples shares macrophages, secretion
- GSE233051 A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model. 36 samples shares steatohepatitis, non-alcoholic
- GSE256502 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_isolated_cells] 31 samples shares steatohepatitis, non-alcoholic
- GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples shares macrophages, cytokine
- GSE248077 Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis 13 samples shares steatohepatitis, non-alcoholic
- GSE272755 Transcriptional effects of lysosome stress on mouse bone marrow-derived macrophages and primary microglia 263 samples shares macrophages
- GSE319684 Timecourse of FACS sorted Ly6C+ monocytes, tissue resident alveolar macrophages (trAMs), monocyte derived alveolar macrophages (bmAMs) and epithelial cells from SARS-CoV-2 (maVie16) vs. IAV (PR8) infected mouse lungs 176 samples shares macrophages
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.