← BioTransfer GEO Dataset Finder
GEO series

Gene expression profiling of Trophoblast Stem Cells with Progesterone Receptor (PGR) knockdown

GSE265928 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/26 Platform GPL10999
Summary
As medical abortion has established itself as the significant method of terminating pregnancies, many studies in recent years has focused on Mifepristone, a principal agent used in this field. It can be found that much effort has been devoted to the research on the impact of Mifepristone on the decidua and embryo implantation process in the mechanism of abortion and contraception; the mechanism of its impact on trophoblast cells, however, still remains unclear. Therefore, the present study aims to fill the gap by investigating the effects of Mifepristone on villous trophoblasts in medical abortion patients. We have found that Mifepristone affects trophoblast cell proliferation and invasion through the progesterone receptor. We established PGR-knockdown trophoblast stem cells and collected these cells for comprehensive RNA-seq analysis.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE265928_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1104984 and SRA study SRP504177. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.