The chromatin remodeler CHD1L controls human cortical neurogenesis and contributes to distal 1q21.1 deletion/duplication syndrome.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 29 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 29 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variantNucleic acids research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266032_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1105366 and SRA study SRP536437. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 10 samples read as cases, 5 as controls.
How we read this: 6 replicated groups read from 29 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8239653 8330_ATAC-seq_1 8330_ATAC-seq
- GSM8239654 8330_ATAC-seq_2 8330_ATAC-seq
- GSM8239655 8330_ATAC-seq_3 8330_ATAC-seq
- GSM8239656 8330_ATAC-seq_4 8330_ATAC-seq
- GSM8239657 A5_ATAC-seq_1 A5_ATAC-seq
- GSM8239658 A5_ATAC-seq_2 A5_ATAC-seq
- GSM8239659 A5_ATAC-seq_3 A5_ATAC-seq
- GSM8239660 A5_ATAC-seq_4 A5_ATAC-seq
- GSM8239661 A12_ATAC-seq_1 A12_ATAC-seq
- GSM8239662 A12_ATAC-seq_2 A12_ATAC-seq
- GSM8239663 A12_ATAC-seq_3 A12_ATAC-seq
- GSM8239664 A12_ATAC-seq_4 A12_ATAC-seq
- GSM8239665 Control 8 330_RNA-seq_1 Control 8 330_RNA-seq
- GSM8239666 Control 8 330_RNA-seq_2 Control 8 330_RNA-seq
- GSM8239667 Control 8 330_RNA-seq_3 Control 8 330_RNA-seq
- GSM8239668 Mutant A5_RNA-seq_1 Mutant A5_RNA-seq
- GSM8239669 Mutant A5_RNA-seq_2 Mutant A5_RNA-seq
- GSM8239670 Mutant A5_RNA-seq_3 Mutant A5_RNA-seq
- GSM8239671 Mutant A12_RNA-seq_1 Mutant A12_RNA-seq
- GSM8239672 Mutant A12_RNA-seq_2 Mutant A12_RNA-seq
- GSM8239673 Mutant A12_RNA-seq_3 Mutant A12_RNA-seq
- GSM8239674 8330_Control_multiome_ATAC
- GSM8239675 8330_Control_multiome_RNA
- GSM8239676 A12_Mutant_multiome_ATAC
- GSM8239677 A12_Mutant_multiome_RNA
- GSM8553900 CUT&RUN CHD1L
- GSM8553901 CUT&RUN HK4me2
- GSM9088841 CUT&RUN CHD1L in Mutant Line 1 hNPC
- GSM9088842 CUT&RUN CHD1L in Mutant Line 2 hNPC
- GSE266029 The chromatin remodeler CHD1L controls human cortical neurogenesis and contributes to distal 1q21.1 deletion/duplication syndrome [ATAC-seq] 12 samples shares chd1l, 1q21, neurogenesis, contributes, duplication, chromatin, remodeler, controls
- GSE266030 The chromatin remodeler CHD1L controls human cortical neurogenesis and contributes to distal 1q21.1 deletion/duplication syndrome [RNA-seq] 9 samples shares chd1l, 1q21, neurogenesis, contributes, duplication, chromatin, remodeler, controls
- GSE275343 Coordinated gene expression within persistent STAT3-associated chromatin conformations contributes to hepatocellular carcinoma progression [CHIP-seq] 42 samples shares contributes, chromatin
- GSE275342 Coordinated gene expression within persistent STAT3-associated chromatin conformations contributes to hepatocellular carcinoma progression [RNA-seq] 16 samples shares contributes, chromatin
- GSE305661 Targeting CHD1L Suppresses Prostate Cancer Progression via the FOXO3-PUMA Axis 6 samples shares chd1l
- GSE268609 A roadmap to human hippocampal neurogenesis in adulthood, aging and AD 78 samples shares neurogenesis
- GSE307094 Single-cell transcriptional patterns impairment in an adult neurogenesis model of Alzheimer´s disease 18 samples shares neurogenesis
- GSE4271 Molecular subclasses of high-grade glioma: prognosis, disease progression, and neurogenesis 200 samples shares neurogenesis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.