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Divergent gene expression and kinetics of circulating tumor-infiltrating lymphocytes with highly homologous T-cell receptor sequences during immunotherapy

GSE266035 Homo sapiens Expression profiling by high throughput sequencing; Other 9 samples Submitted 2025/02/20 Platform GPL24676
Summary
single-cell RNA/TCR sequencing (scRNA/TCR-seq) of circulating T cells from longitudinally obtained blood samples from the same a patient with NSCLC who had a response and a subsequent progression to anti-PD-1/CTLA-4 blockade therapy.
Published in
Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy
Kajihara R, Long MD, Hoki T et al. · Journal for immunotherapy of cancer 2025 · PMID 39863301 · doi:10.1136/jitc-2024-010092
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Direct links to NCBI, no account and no request form: the whole study as GSE266035_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1105373 and SRA study SRP504409. Searching any of these in the dataset finder brings you back here.

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