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Etoposide promotes tumor cells pyroptosis via down-regulation of O-GlcNAcylation to regulating p53 stability

GSE266073 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/20 Platform GPL20795
Summary
As a new type of cell death mediated by Gasdermin (GSDM) family, pyroptosis has increasingly become a research hotspot in the fields of biology and medicine. Studies have found that a variety of drugs (such as etoposide and traditional Chinese medicine extracts) can effectively inhibit the occurrence and development of tumors by activating caspase family and GSDM protein family to induce pyroptosis. Promoting pyroptosis has become an effective method for the treatment of tumors, but the research on its regulatory mechanism is still lacking. In order to explore the key molecular pathways of etoposide-induced pyroptosis, transcriptome sequencing analysis was performed
Published in
Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability
Wang J, Wang Y, Xiao H et al. · The Journal of biological chemistry 2025 · PMID 39667498 · doi:10.1016/j.jbc.2024.108050
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Also filed as BioProject PRJNA1105635 and SRA study SRP504491. Searching any of these in the dataset finder brings you back here.

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