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Single-nucleus transcriptomics and chromatin accessibility of cell type-specific contributions to the epileptogenic cortex of focal cortical dysplasia type IIIa [snATAC-seq]

GSE266303 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2024/10/30 Platform GPL24676
Summary
Focal cortical dysplasia (FCD) is a heterogeneous group of cortical developmental malformations that constitute a common cause of medically intractable epilepsy. Multiomic integration was conducted via single-nucleus RNA sequencing (snRNA-seq) and single-nucleus assays for transposase-accessible chromatin sequencing (snATAC-seq) to analyse cell type-specific alterations in chromatin accessibility and correlate them with gene expression changes in the epileptogenic cortex of FCD type IIIa (FCD IIIa).
Published in
Excitatory neurons and oligodendrocyte precursor cells are vulnerable to focal cortical dysplasia type IIIa as suggested by single-nucleus multiomics
Liu Y, Li Y, Zhang Y et al. · Clinical and translational medicine 2024 · PMID 39440467 · doi:10.1002/ctm2.70072
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Also filed as BioProject PRJNA1106531 and SRA study SRP505058. Searching any of these in the dataset finder brings you back here.

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