GEO series
Reprogramming of diabetic wounds by Sox2 triggers a pro-healing transcriptional signature
GSE266638
Mus musculus
Expression profiling by high throughput sequencing
14 samples
2024/07/22
GPL19057GPL24247
Summary
We show that a combinatorial upregulation of SOX2 and hyperglycemia in cutaneous keratinocytes triggers a pro-healing signature and increased neutrophil chemoattraction, putatively by Ccr2, Ccr5, and Csf3r signaling. Neutrophil depletion and deregulation through the TREM1/FOXM1 pathway are directly implicated in diabetic foot ulcer (DFU) pathophysiology. Our results highlight the role of neutrophil recruitment in wound healing and can be used to explore potential therapeutic targets for DFUs in patients.
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Paper (PMID 39127091) ↗
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