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Effect of PIM447 treatment on gene expression of M07e cells transduced with JAK3 Q988P

GSE266986 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/07/15 Platform GPL24676
Summary
To test whether the activity of PIM proteins promotes an aberrant activation of the molecular cascades that are essential for the leukemogenic effects mediated by JAK/STAT pathway mutations, we analyzed RNA-seq data from M07e cells expressing JAK3Q988P that were treated with PIM447 or left untreated.
Published in
PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK/STAT pathway mutations in T-ALL/LBL
Lahera A, Vela-Martín L, Fernández-Navarro P et al. · NPJ precision oncology 2024 · PMID 39033228 · doi:10.1038/s41698-024-00638-2
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Also filed as BioProject PRJNA1109296 and SRA study SRP506443. Searching any of these in the dataset finder brings you back here.

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