← BioTransfer GEO Dataset Finder
GEO series

Effect of mRNA vaccine on Epigenetic and Transcriptomic Profiles of Kupffer Cells (CUT&RUN)

GSE267043 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/11/06 Platform GPL28457
Summary
Analysis of genome wide distribution of an active histone mark, trimethylated lysine 4 on histone H3 protein subunit (H3K4me3) showed that an mRNA/LNP immunization resulted in increased H3K4me3 in the regulatory regions of various genes, the expression of some of which were upregulated. In addition, H3k4me3 may indicate that the chromatins of some genes are in the “poised” state where it will influence the expression upon next stimuli.
Published in
Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80(+) liver-associated macrophages
Pongma C, Keawvilai P, Boonmee A et al. · Scientific reports 2025 · PMID 39774150 · doi:10.1038/s41598-025-85234-5
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE267043_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1109400 and SRA study SRP506599. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.