GEO series
Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double-stranded RNA [RNAseq]
GSE267104
Homo sapiens
Expression profiling by high throughput sequencing
17 samples
2025/04/16
GPL24676GPL21697
Summary
Acute loss of INT induces transcription factors that initiate stress-responses like the Integrated Stress Response (ISR). Inefficient elongation upon INT loss enables termination in introns and dsRNA formation. dsRNA is recognized by PKR, which persistently activates the ISR in samples from patients with INT mutations
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Paper (PMID 40233738) ↗
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