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Transcriptomics analysis of white adipose tissue, gastrocnemius muscle and liver tissues from Ogg1Tg mice.

GSE267211 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/15 Platform GPL17021
Summary
Obesity is associated with increased oxidative stress that damages genomic and mitochondrial DNA. Oxidatively-induced lesions in both DNA pools are repaired via the base-excision repair pathway, initiated by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). Global deletion of OGG1 and common OGG1 polymorphisms render mice and humans susceptible to metabolic disease. Moreover, mice with transgenic targeting of OGG1 to mitochondria (Ogg1Tg mice) confer significant protection from diet-induced obesity, insulin resistance, and adipose tissue inflammation. Here, we analyzed transcriptomics of gastrocnemius muscle from Ogg1Tg mice and control mice (C57BL/6J mice) by bulk RNA sequencing (RNAseq).
Published in
OGG1 increases exercise endurance via elevated skeletal muscle FGF21
Blaze B, Sharma P, Gupta BP et al. · The Journal of biological chemistry 2026 · PMID 41812879 · doi:10.1016/j.jbc.2026.111360
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Direct links to NCBI, no account and no request form: the whole study as GSE267211_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1110250 and SRA study SRP507013. Searching any of these in the dataset finder brings you back here.

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