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Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by RNA-seq.

GSE267213 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/05 Platform GPL24676
Summary
Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approximately one-third of the vehicles worldwide use diesel, there are growing concerns on the risks posed by DEP to human health. Long-term exposure to DEP is associated with airway hyperresponsiveness, pulmonary fibrosis, and inflammation; however, the molecular mechanisms behind the effects of DEP on the respiratory tract are poorly understood. Such mechanisms can be addressed by examining transcriptional and DNA methylation changes. In this study, we investigated the effect of 4 weeks exposure to 30 μg/ml DEP on gene expression levels in A549 cells.
Published in
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Lukyanchuk A, Muraki N, Kawai T et al. · Epigenetics & chromatin 2024 · PMID 39103936 · doi:10.1186/s13072-024-00549-3
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Also filed as BioProject PRJNA1110256 and SRA study SRP507048. Searching any of these in the dataset finder brings you back here.

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