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USP20 promotes T-ALL evolution by deubiquitinating modified HIF1A

GSE267258 Homo sapiens Expression profiling by high throughput sequencing; Other 8 samples Submitted 2025/08/31 Platform GPL24676
Summary
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. The potential of investigating USP20 holds promise for more targeted therapies and better outcomes. Knocking down USP20 led to decreased T-ALL cell survival and growth both in vitro and in vivo, similar to using the USP20 inhibitor GSK2643943A. To explore USP20-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the USP20-knockdown J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of USP20 with HIF1a on chromatin in J.gamma1 cells.
Published in
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination
Xu L, Zhang Z, Yu J et al. · Acta pharmaceutica Sinica. B 2025 · PMID 41049757 · doi:10.1016/j.apsb.2025.07.003
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Also filed as BioProject PRJNA1110766 and SRA study SRP507192. Searching any of these in the dataset finder brings you back here.

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