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SWI/SNF chromatin-remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cells migration [CUT&Tag]

GSE267296 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/07/01 Platform GPL17021
Summary
Regulatory T (Treg) cells play a critical regulatory role in the immune system by suppressing excessive immune responses and maintaining immune balance. The effective migration of Treg cells is crucial for controlling the development and progression of inflammatory diseases. However, the epigenetic mechanisms responsible for directing Treg cells into the inflammatory tissue remain incompletely elucidated. In this study, we identified BAF60b, a subunit of SWI/SNF chromatin remodeling complexes, as a positive regulator of Treg cells migration that inhibits the progression of inflammation in experimental autoimmune encephalomyelitis (EAE) and colitis animal models. Mechanistically, transcriptome and genome-wide chromatin landscaped analyses demonstrated that BAF60b interacts with the transcription factor RUNX1 to promote the expression of CCR9 on Treg cells, which in turn affects their ability to migrate to inflammatory tissues. Our work provides insights into the essential role of BAF60b in regulating Treg cells migration and its impact on inflammatory diseases.
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Direct links to NCBI, no account and no request form: the whole study as GSE267296_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1052954 and SRA study SRP478215. Searching any of these in the dataset finder brings you back here.

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