← BioTransfer GEO Dataset Finder
GEO series

mTOR activity paces human blastocyst stage developmental progression

GSE267302 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/09/24 Platform GPL24676
Summary
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway. It is unknown whether this ability is conserved in mammals in general and in humans in particular. Here we show that decreasing the activity of the mTOR signaling pathway induces human pluripotent stem cells (hPSCs) and blastoids to enter a dormant state with limited proliferation, developmental progression, and capacity to attach to endometrial cells. These in vitro assays show that, similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage and is reversible at both functional and molecular levels. The pacing of human blastocyst development has potential implications for reproductive therapies
Published in
mTOR activity paces human blastocyst stage developmental progression
Iyer DP, Khoei HH, van der Weijden VA et al. · Cell 2024 · PMID 39332412 · doi:10.1016/j.cell.2024.08.048
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE267302_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1111016 and SRA study SRP507307. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.