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RNA profiling of CSF resident macrophages and monocyte-macrophages from leptomeningeal metastasis mice

GSE267325 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/24 Platform GPL24247
Summary
We investigated the functional effect of dura-derived leptomeningeal matastasis (LM)-associated macrophages (dLAMs) on the cerebrospinal fluid (CSF) niche during LM outgrowth. Using lung cancer leptomeningeal metastasis models of Cx3cr1CreER:mTmG mice with tamoxifen administration, we achieved dLAMs and monocyte-macrophages via fluorescence-activated cell sorting (FACS). Then we performed bulk RNAseq analysis for these two cell populations.
Published in
Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion
Zhao J, Zeng R, Li X et al. · Nature cancer 2024 · PMID 39710801 · doi:10.1038/s43018-024-00858-2
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Also filed as BioProject PRJNA1111061 and SRA study SRP510346. Searching any of these in the dataset finder brings you back here.

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