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Transcriptomic analysis of human vascular endothelial cell line (EA.hy926) exposed to okadaic acid

GSE267374 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/18 Platform GPL18573
Summary
As the climate changes due to global warming, the frequency of appearance of marine-derived toxins increases. In particular, the need to investigate marine-derived toxins for which toxicity has not yet been identified is emerging. Blood vessels are passageways through which compounds entering the body move to various organs and are the sites first exposed to compounds. Therefore, it is important to know the effects of compounds on blood vessels when they enter the body. In this study, the human vascular endothelial cell line EA.hy926 was exposed to the marine toxins OA (IC20; 42.9 nM) and the mechanism of toxicity was investigated at the transcriptome level. Quantseq 3' mRNA sequencing was performed by extracting RNA from EA.hy926 cells exposed to the toxins. Differentially expressed genes were determined based on fold change ≥ 1.5 and P value < 0.05.
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Direct links to NCBI, no account and no request form: the whole study as GSE267374_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1111366 and SRA study SRP507506. Searching any of these in the dataset finder brings you back here.

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