IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Super-Enhancer-Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T-ALL Cell Growth and SurvivalAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267451_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1111543 and SRA study SRP507635. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 5 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8266942 J.gamma1,ELF1,CUT&Tag,rep1 J.gamma1,ELF1,CUT&Tag,
- GSM8266943 J.gamma1,ELF1,CUT&Tag,rep2 J.gamma1,ELF1,CUT&Tag,
- GSM8266944 J.gamma1,ERG,CUT&Tag,rep1 J.gamma1,ERG,CUT&Tag,
- GSM8266945 J.gamma1,ERG,CUT&Tag,rep2 J.gamma1,ERG,CUT&Tag,
- GSM8266946 J.gamma1,IRF2BP2,CUT&Tag,rep1 J.gamma1,IRF2BP2,CUT&Ta…
- GSM8266947 J.gamma1,IRF2BP2,CUT&Tag,rep2 J.gamma1,IRF2BP2,CUT&Ta…
- GSM8266948 J.gamma1,RUNX1,CUT&Tag,rep1 J.gamma1,RUNX1,CUT&Tag,
- GSM8266949 J.gamma1,RUNX1,CUT&Tag,rep2 J.gamma1,RUNX1,CUT&Tag,
- GSM8287877 J.gamma1,ETS1,CUT&Tag,rep1 J.gamma1,ETS1,CUT&Tag,
- GSM8287878 J.gamma1,ETS1,CUT&Tag,rep2 J.gamma1,ETS1,CUT&Tag,
- GSE302930 Epigenetic Atlas of Bladder Cancer Reveals Master Transcription Factors and Risk-Associated Regulatory Elements in Luminal and Basal-Squamous Molecular Subtypes 92 samples shares transcription, factors, master
- GSE275721 Lineage master regulator and cancer-selective partner transcription factors rewire 3D genome topology for tumor-specific gene control 72 samples shares transcription, factors, master
- GSE293334 Allelic topological centering by transcription factors drives oncogenic multi-enhancer transcriptional regulation [ChIP-seq] 60 samples shares transcription, factors
- GSE301298 Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency 88 samples shares transcription, factors
- GSE310664 Analysis of experimental colorectal liver metastases identifies distinct proliferation independent transcriptional programs in micro- versus macrometastases 22 samples shares proliferation, transcription
- GSE307817 A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease 12 samples shares proliferation, transcription
- GSE284519 TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [ChIP-seq] 93 samples shares transcription
- GSE296190 Hypoxic regulation of chromatin and gene transcription [ChIP-seq] 84 samples shares transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.