Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [CUT&RUN]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- MedulloblastomaThis series is part of our curated briefing on it.
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267470_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1111557 and SRA study SRP507676. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8267128 D458 cells, IgG, DMSO, replicate 1, ChIP
- GSM8267129 D458 cells, IgG, DMSO, replicate 2, ChIP
- GSM8267130 D458 cells, Myc, DMSO, replicate 1, ChIP
- GSM8267131 D458 cells, Myc, DMSO, replicate 2, ChIP
- GSM8267132 D458 cells, IgG, TG02, replicate 1, ChIP
- GSM8267133 D458 cells, IgG, TG02, replicate 2, ChIP
- GSM8267134 D458 cells, Myc, TG02, replicate 1, ChIP
- GSM8267135 D458 cells, Myc, TG02, replicate 2, ChIP
- GSM8267136 D458 cells, H3K4me1, replicate 1, ChIP
- GSM8267137 D458 cells, H3K4me1, replicate 2, ChIP
- GSM8267138 D458 cells, IgG, replicate 1, ChIP
- GSM8267139 D458 cells, IgG, replicate 2, ChIP
- GSE267473 Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma 38 samples same disease briefing · shares medulloblastoma, transcription, processive, myc-driven, targeting, circuitry
- GSE267469 Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [RNA-seq] 24 samples same disease briefing · shares medulloblastoma, transcription, processive, myc-driven, targeting, circuitry
- GSE270125 Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency [CUT&Run] 169 samples same disease briefing · shares cut, run, medulloblastoma
- GSE280973 Transcriptional Regulation of Protein Synthesis by Mediator Kinase Represents a Therapeutic Vulnerability in MYC-driven Medulloblastoma 20 samples same disease briefing · shares medulloblastoma, transcription, myc-driven
- GSE229150 The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma 30 samples same disease briefing · shares medulloblastoma, transcription
- GSE291915 The Hira complex regulates Gli3R-dependent transcription in Hedgehog signaling and medulloblastoma cell growth and migration [RNA-seq] 12 samples same disease briefing · shares medulloblastoma, transcription
- GSE37385 Subgroup specific somatic copy number aberrations in the medulloblastoma genome 1382 samples same disease briefing · shares medulloblastoma
- GSE270126 Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency. 219 samples same disease briefing · shares medulloblastoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.