GEO series
The MUC5B IPF risk variant promotes a distal airway secretory phenotype and loss of alveolar markers
GSE267521
Homo sapiens
Expression profiling by high throughput sequencing
310 samples
2024/07/29
GPL24676
Summary
The dominant risk factor for the development of idiopathic pulmonary fibrosis (IPF) is a common variant in the promoter region of the airway mucin MUC5B, variant rs35705950. The MUC5B promoter variant enhances MUC5B expression in the terminal respiratory bronchiole, where it is normally absent. We pursued a spatial gene expression approach to understand how the MUC5B variant influences IPF in age-matched unaffected and IPF lung tissue specimens.
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Paper (PMID 38924494) ↗
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