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Effect of the FGFR kinase inhibitors AZD4547 and BGJ398 on gene expression in HaCaT cells

GSE267537 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/11/17 Platform GPL24676
Summary
Fibroblast growth factors (FGF) play important roles during embryonic development as well as in the adult organism in tissue homeostasis, regeneration, repair and metabolism. We recently showed that inhibition of FGF receptor (FGFR) signaling in keratinocytes either pharmacologically or in a mouse FGFR1/2 knockout model, promoted expression of interferon-stimulated genes (ISGs) (Maddaluno et al, 2020). Here we analyzed the transcriptome of human HaCaT keratinocytes in response to treatment with the FGFR kinase inhibitors AZD4547 and BGJ398.
Published in
FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases
Stefanova D, Olszewski D, Glitscher M et al. · Cellular and molecular life sciences : CMLS 2024 · PMID 39621133 · doi:10.1007/s00018-024-05502-x
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Also filed as BioProject PRJNA1111790 and SRA study SRP508387. Searching any of these in the dataset finder brings you back here.

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