Gain-of-function RNA Polymerase II partitioning is a shared feature of diverse oncogenic fusions
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RNA polymerase II partitioning is a shared feature of diverse oncofusion condensatesCell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267717_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1112450 and SRA study SRP508221. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8273645 ACHN, H3K27ac, ChIP
- GSM8273646 ACHN, input
- GSM8273647 ACHN, RPB1, ChIP
- GSM8273648 ACHN, TFE3, ChIP
- GSM8273649 XP121, H3K27ac, ChIP
- GSM8273650 XP121, input
- GSM8273651 XP121, RPB1, ChIP
- GSM8273652 XP121, TFE3, ChIP
- GSM8671666 XP121, NT, TFE3, ChIP
- GSM8671667 XP121, NT, RPB1, ChIP
- GSM8671668 XP121, NT, input
- GSM8671669 XP121, shRNA, TFE3, ChIP
- GSM8671670 XP121, shRNA, RPB1, ChIP
- GSM8671671 XP121, shRNA, input
- GSE266407 ESR1 fusions invoke breast cancer subtype-dependent enrichment of ligand independent oncogenic signatures and phenotypes [ChIP-seq] 14 samples shares oncogenic, fusions
- GSE243499 Mutant FOXO1 Controls an Oncogenic Network via Enhancer Accessibility and RNA Polymerase Pause Release 79 samples shares polymerase, oncogenic
- GSE277183 RNA Polymerase II coordinates histone deacetylation at active promoters 158 samples shares polymerase
- GSE292907 Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [ChIP-seq] 97 samples shares polymerase
- GSE265881 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (ChIP-Seq) 72 samples shares polymerase
- GSE265883 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (CUT&RUN) 68 samples shares polymerase
- GSE202761 Receptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [ChIP-seq] 64 samples shares polymerase
- GSE284654 Nucleolar Stress-inducing Compounds Influence rDNA occupancy of RNA Polymerase I Transcription Machinery 64 samples shares polymerase
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.