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Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in Desmoplastic Small Round Cell Tumors [ATAC-seq]

GSE267807 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/05/22 Platform GPL24676
Summary
Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, aggressive sarcoma driven by the EWSR1-WT1 chimeric transcription factor. Despite this unique oncogenic driver, DSRCT displays a polyphenotypic differentiation of unknown causality. Using single-cell multi-omics on samples from patients, we find that DSRCT tumor cells cluster into consistant subpopulations with partially overlapping lineage- and metabolism-related transcriptional programs.
Published in
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs
Henon C, Vibert J, Eychenne T et al. · Cell reports. Medicine 2024 · PMID 38781959 · doi:10.1016/j.xcrm.2024.101582
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Also filed as BioProject PRJNA1113159 and SRA study SRP508496. Searching any of these in the dataset finder brings you back here.

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