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Effect of knockdown of GRP94 on gene expression of MKN-45 cells

GSE267811 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/25 Platform GPL24676
Summary
Anoikis resistance allows cancer cells to avoid death caused by detachment from the extracellular matrix's adhesion, enabling these cells to infiltrate and migrate to regions such as the peritoneum.Glucose-regulated protein 94 (GRP94, alternatively labeled as HSP90B1) is typically stress-induced and is part of the heat shock protein 90 (Hsp90) family.GRP94 is closely tied to cellular resistance to stress, apoptosis, proliferation, invasion, inflammation, and immunity.Our findings indicated that while attached culture didn't impact the apoptosis rate between shGRP94 and shCtrl groups, GRP94 knockdown weakened anoikis resistance, migration, and invasion abilities. Here, we aim to assess the impact of knocking down GRP94 on gene expression in the gastric cancer cell line MKN-45, to further elucidate potential molecular mechanisms by which GRP94 affects the biological characteristics of gastric cancer cells.
Published in
GRP94 promotes anoikis resistance and peritoneal metastasis through YAP/TEAD1 pathway in gastric cancer
Shi Q, Lu Y, Du Y et al. · iScience 2024 · PMID 39252968 · doi:10.1016/j.isci.2024.110638
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Also filed as BioProject PRJNA1113161 and SRA study SRP508504. Searching any of these in the dataset finder brings you back here.

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