Exploring the mechanism of AGR2 regulating the progression of pancreatic ductal adenocarcinoma and remodeling of the tumor microenvironment
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Pancreatic cancerThis series is part of our curated briefing on it.
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapyCell reports. Medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267820_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1113316 and SRA study SRP508558. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8279259 Panc1 cells, sgControl, rep1 Panc1 cells, sgControl,
- GSM8279260 Panc1 cells, sgControl, rep2 Panc1 cells, sgControl,
- GSM8279261 Panc1 cells, sgControl, rep3 Panc1 cells, sgControl,
- GSM8279262 Panc1 cells, sgAGR2, rep1 Panc1 cells, sgAGR2,
- GSM8279263 Panc1 cells, sgAGR2, rep2 Panc1 cells, sgAGR2,
- GSM8279264 Panc1 cells, sgAGR2, rep3 Panc1 cells, sgAGR2,
- GSM8279265 Capan2 cells, sgControl, rep1 Capan2 cells, sgControl,
- GSM8279266 Capan2 cells, sgControl, rep2 Capan2 cells, sgControl,
- GSM8279267 Capan2 cells, sgControl, rep3 Capan2 cells, sgControl,
- GSM8279268 Capan2 cells, sgAGR2, rep1 Capan2 cells, sgAGR2,
- GSM8279269 Capan2 cells, sgAGR2, rep2 Capan2 cells, sgAGR2,
- GSM8279270 Capan2 cells, sgAGR2, rep3 Capan2 cells, sgAGR2,
- GSM8279271 CAF, Control,rep1 CAF, Control,
- GSM8279272 CAF, Control,rep2 CAF, Control,
- GSM8279273 CAF, Control,rep3 CAF, Control,
- GSM8279274 CAF, AGR2,rep1 CAF, AGR2,
- GSM8279275 CAF, AGR2,rep2 CAF, AGR2,
- GSM8279276 CAF, AGR2,rep3 CAF, AGR2,
- GSM8279277 CAF, TGFb,rep1 CAF, TGFb,
- GSM8279278 CAF, TGFb,rep2 CAF, TGFb,
- GSM8279279 CAF, TGFb,rep3 CAF, TGFb,
- GSM8279280 CAF, IL1A,rep1 CAF, IL1A,
- GSM8279281 CAF, IL1A,rep2 CAF, IL1A,
- GSM8279282 CAF, IL1A,rep3 CAF, IL1A,
- GSE179351 Radiation Therapy Inhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial 54 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE288221 RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines 32 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE111672 Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas 23 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE150043 Deeper insight into Pancreatic Ductal Adenocarcinoma (PDAC) survival heterogeneity using integrative analyses of individual and global transcriptome based networks 19 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE224502 RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down 18 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE135731 Genome-wide identification of circular RNAs with critical roles in pancreatic ductal adenocarcinoma 3 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE71729 Virtual Microdissection of Pancreatic Ductal Adenocarcinoma Reveals Tumor and Stroma Subtypes. 357 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE102238 Gene expression signatures associated with Perineural Invasion in pancreatic ductal adenocarcinoma 100 samples same disease briefing · shares adenocarcinoma, pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.