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Hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment

GSE267933 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/14 Platform GPL17021
Summary
This study investigates the roles of neurons, microglia, astrocytes, and oligodendrocytes in the pathogenesis of postoperative cognitive impairment, focusing on a dysregulated glia-neuron cycle. We utilized 18-month male C57BL/6 mice to model this condition, conducting single-cell RNA sequencing in the hippocampus to explore the neuroglial interactions and their implications in neuroinflammation, synaptic dysfunction, and myelin loss. This dataset includes transcriptomic profiles aimed at decoding the cellular communication in aged hippocampal cells and assessing the impact of therapeutic interventions on postoperative cognitive decline.
Published in
Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment
Suo Z, Xiao T, Qu Y et al. · Aging cell 2025 · PMID 39540334 · doi:10.1111/acel.14406
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Direct links to NCBI, no account and no request form: the whole study as GSE267933_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1113658 and SRA study SRP508801. Searching any of these in the dataset finder brings you back here.

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