Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 27 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer's disease mouse modelActa neuropathologica communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267989_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1113999 and SRA study SRP508960. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 27 sample titles: 27 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8283394 J veh. inj.
- GSM8283395 J veh. con.
- GSM8283396 K R33 inj.
- GSM8283397 K R33 con.
- GSM8283398 AE R33 inj.
- GSM8283399 M veh. inj.
- GSM8283400 M veh. con.
- GSM8283401 P R55 con.
- GSM8283402 P R55 inj.
- GSM8283403 O R33 inj.
- GSM8283404 O R33 con.
- GSM8283405 AA R55 inj.
- GSM8283406 AA R55 con.
- GSM8283407 Q R55 inj.
- GSM8283408 R R55 inj.
- GSM8283409 Q R55 con.
- GSM8283410 N R33 inj.
- GSM8283411 L veh. con.
- GSM8283412 R R55 con.
- GSM8283413 L veh. inj.
- GSM8283414 N R33 con.
- GSM8283415 AH veh. con.
- GSM8283416 AH veh. inj.
- GSM8283417 AD R33 con.
- GSM8283418 AD R33 inj.
- GSM8283419 AB R55 con.
- GSM8283420 AB R55 inj.
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- GSE277167 Protective variant in PLCγ2 mitigates Alzheimer’s disease associated pathology via enhancing beneficial microglia functions 31 samples shares enhancing, alzheimer
- GSE302245 Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease 16 samples shares dysfunction, alzheimer
- GSE294772 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging [snATAC-Seq] [10X Multiome] 142 samples shares dysfunction, stability
- GSE283382 N6-methyladenosine modulate second cell fate decision by enhancing mRNA stability of pivotal transcription factors during primitive endoderm development [TBLC_RNAseq] 98 samples shares enhancing, stability
- GSE274875 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [Cut & Run] 38 samples shares dysfunction, complex
- GSE329430 Bone marrow myelopoiesis dysfunction in Alzheimer’s disease 20 samples shares dysfunction, alzheimer
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.