Mutant GFAP alters lineage commitment of neural organoids
RNA-seq (gene expression) · human · 79 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 79 samples: 55 distinct titles, 8 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mutations in GFAP Alter Early Lineage Commitment of OrganoidsGlia · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267992_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1113998 and SRA study SRP507754. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 79 sample titles: 55 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8267497 control, day 3, replicate 1
- GSM8267498 control, day 3, replicate 2
- GSM8267499 control, day 3, replicate 3
- GSM8267500 control, day 3, replicate 4
- GSM8267501 AxD, day 3, replicate 1
- GSM8267502 AxD, day 3, replicate 2
- GSM8267503 AxD, day 3, replicate 3
- GSM8267504 AxD, day 3, replicate 4
- GSM8267505 control, day 5, replicate 1
- GSM8267506 control, day 5, replicate 2
- GSM8267507 control, day 5, replicate 3
- GSM8267508 control, day 5, replicate 4
- GSM8267509 AxD, day 5, replicate 1
- GSM8267510 AxD, day 5, replicate 2
- GSM8267511 AxD, day 5, replicate 3
- GSM8267512 AxD, day 5, replicate 4
- GSM8267513 control, day 7, replicate 1
- GSM8267514 control, day 7, replicate 2
- GSM8267515 control, day 7, replicate 3
- GSM8267516 control, day 7, replicate 4
- GSM8267517 AxD, day 7, replicate 1
- GSM8267518 AxD, day 7, replicate 2
- GSM8267519 AxD, day 7, replicate 3
- GSM8267520 AxD, day 7, replicate 4
- GSM8267521 control, day 9, replicate 1
- GSM8267522 control, day 9, replicate 2
- GSM8267523 control, day 9, replicate 3
- GSM8267524 control, day 9, replicate 4
- GSM8267525 AxD, day 9, replicate 1
- GSM8267526 AxD, day 9, replicate 2
- GSM8267527 AxD, day 9, replicate 3
- GSM8267528 AxD, day 9, replicate 4
- GSM8283421 control, day 3, replicate 1, direct-seeding
- GSM8283422 control, day 3, replicate 3, direct-seeding
- GSM8283423 AxD, day 3, replicate 1, direct-seeding
- GSM8283424 AxD, day 3, replicate 2, direct-seeding
- GSM8283425 AxD, day 3, replicate 3, direct-seeding
- GSM8283426 control, day 5, replicate 1, direct-seeding
- GSM8283427 control, day 5, replicate 2, direct-seeding
- GSM8283428 control, day 5, replicate 3, direct-seeding
+ 39 more — browse all 79 samples with per-sample file links →
- GSE267990 Mutant GFAP alters lineage commitment of neural organoids [AxDorganoids_bulk_experiment2] 47 samples shares gfap, commitment, organoids, lineage, mutant, alters, neural
- GSE303838 MECP2 Mutations Rewire Human ESC Fate and Bias Cortical Lineage Commitment [RNA-Seq] 48 samples shares commitment, lineage
- GSE289912 APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids 32 samples shares organoids, alters
- GSE331395 Replicative senescence in neural progenitors induces senescence-associated markers in midbrain organoids 24 samples shares organoids, neural
- GSE281002 Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages 15 samples shares organoids, lineage
- GSE302350 KMT2D-deficiency destabilizes lineage progression in immature neural progenitors 16 samples shares lineage, neural
- GSE277967 Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols [time-course bulk RNA-seq] 768 samples shares organoids
- GSE210993 RNA sequencing of human gastrointestinal organoids and Intestinal Metaplasia (IM) organoids 103 samples shares organoids
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.