Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 61 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 61 samples: 24 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cellsNature cell biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268091_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1114645 and SRA study SRP508308. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 60 samples.
How we read this: 24 replicated groups read from 61 sample titles; they account for 60 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8275003 CompBasal_rep1 CompBasal
- GSM8275004 CompBasal_rep2 CompBasal
- GSM8275005 Basal_cnl_rep1 Basal_cnl
- GSM8275006 Basal_cnl_rep2 Basal_cnl
- GSM8275007 Basal_cnl_rep3 Basal_cnl
- GSM8275008 CompPluri_rep1 CompPluri
- GSM8275009 CompPluri_rep2 CompPluri
- GSM8275010 CompPluri_rep3 CompPluri
- GSM8275011 Pluri_cnl_rep1 Pluri_cnl
- GSM8275012 Pluri_cnl_rep2 Pluri_cnl
- GSM8275013 Pluri_cnl_rep3 Pluri_cnl
- GSM8275014 IgG_cnl
- GSM8285611 iPS_PluriCnl_H3K27ac_rep1 iPS_PluriCnl_H3K27ac
- GSM8285612 iPS_PluriCnl_H3K27ac_rep2 iPS_PluriCnl_H3K27ac
- GSM8285613 iPS_PluriComp_H3K27ac_rep1 iPS_PluriComp_H3K27ac
- GSM8285614 iPS_PluriComp_H3K27ac_rep2 iPS_PluriComp_H3K27ac
- GSM8285615 iPS_BasalCnl_H3K27ac_rep1 iPS_BasalCnl_H3K27ac
- GSM8285616 iPS_BasalCnl_H3K27ac_rep2 iPS_BasalCnl_H3K27ac
- GSM8285617 iPS_BasalComp_H3K27ac_rep1 iPS_BasalComp_H3K27ac
- GSM8285618 iPS_BasalComp_H3K27ac_rep2 iPS_BasalComp_H3K27ac
- GSM8285619 iPS_HyperPluri_H3K27ac_rep1 iPS_HyperPluri_H3K27ac
- GSM8285620 iPS_HyperPluri_H3K27ac_rep2 iPS_HyperPluri_H3K27ac
- GSM8285621 PluriCnl_24hr_rep1 PluriCnl_24hr
- GSM8285622 PluriCnl_24hr_rep2 PluriCnl_24hr
- GSM8285623 PluriCnl_24hr_rep3 PluriCnl_24hr
- GSM8285624 PluriComp_24hr_rep1 PluriComp_24hr
- GSM8285625 PluriComp_24hr_rep2 PluriComp_24hr
- GSM8285626 BasalCnl_24hr_rep1 BasalCnl_24hr
- GSM8285627 BasalCnl_24hr_rep2 BasalCnl_24hr
- GSM8285628 BasalCnl_24hr_rep3 BasalCnl_24hr
- GSM8285629 BasalCompr_24hr_rep1 BasalCompr_24hr
- GSM8285630 BasalCompr_24hr_rep2 BasalCompr_24hr
- GSM8285631 BasalCompr_24hr_rep3 BasalCompr_24hr
- GSM8285632 HyperPluri_24hr_rep1 HyperPluri_24hr
- GSM8285633 HyperPluri_24hr_rep2 HyperPluri_24hr
- GSM8285634 HyperPluri_24hr_rep3 HyperPluri_24hr
- GSM8285635 HyperBasal_24hr_rep1 HyperBasal_24hr
- GSM8285636 HyperBasal_24hr_rep2 HyperBasal_24hr
- GSM8285637 iPS_BasalCnl_TTseq_rep1 iPS_BasalCnl_TTseq
- GSM8285638 iPS_BasalCnl_TTseq_rep2 iPS_BasalCnl_TTseq
+ 21 more — browse all 61 samples with per-sample file links →
- GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples shares chromatin, state
- GSE270126 Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency. 219 samples shares chromatin, state
- GSE327821 Single-molecule, single-cell profiling of linked chromatin states [Single_cell_CoCUT&Tag] 200 samples shares chromatin, state
- GSE270125 Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency [CUT&Run] 169 samples shares chromatin, state
- GSE327819 Single-molecule, single-cell profiling of linked chromatin states [Bulk_CoCUT&Tag] 35 samples shares chromatin, state
- GSE210848 Lineage specific chromatin modification guides Pax5 mediated gene expression in neuroendocrine like differentiation of prostate cancer 32 samples shares chromatin, state
- GSE314776 Decoding 3D chromatin architecture reveals distinct enhancer classes underlying hierarchical gene regulation in prostate cancer [ChIP-Seq] 24 samples shares chromatin, state
- GSE271175 Genome-wide maps of chromatin state in 142 cancer cell lines [patient] 22 samples shares chromatin, state
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.