Integrator complex bridges TFIID and RNA polymerase II to maintain pluripotency during development (ChIP-Seq)
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 38 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 38 samples: 11 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during developmentMolecular cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268146_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1114761 and SRA study SRP509262. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 34 samples.
How we read this: 11 replicated groups read from 38 sample titles; they account for 34 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8286351 ChIP_INTS11_rep1
- GSM8286352 ChIP_HA_INTS11_rep1
- GSM8286353 ChIP_INTS12_rep1 ChIP_INTS12
- GSM8286354 ChIP_INTS12_rep2 ChIP_INTS12
- GSM8286355 ChIP_RING1B_rep1 ChIP_RING1B
- GSM8286356 ChIP_RING1B_rep2 ChIP_RING1B
- GSM8286357 ChIP_RNA_PolII_rep1 ChIP_RNA_PolII
- GSM8286358 ChIP_RNA_PolII_rep2 ChIP_RNA_PolII
- GSM8286359 ChIP_OCT4_rep1 ChIP_OCT4
- GSM8286360 ChIP_OCT4_rep2 ChIP_OCT4
- GSM8286361 ChIP_SOX2_rep1 ChIP_SOX2
- GSM8286362 ChIP_SOX2_rep2 ChIP_SOX2
- GSM8286363 ChIP_IgG_rep1
- GSM8286364 ChIP_Input
- GSM9057409 ChIP_TAF1_0h_rep1 ChIP_TAF1_0h
- GSM9057410 ChIP_TAF1_0h_rep2 ChIP_TAF1_0h
- GSM9057411 ChIP_TAF1_0h_rep3 ChIP_TAF1_0h
- GSM9057412 ChIP_TAF1_0h_rep4 ChIP_TAF1_0h
- GSM9057413 ChIP_TAF1_3h_rep1 ChIP_TAF1_3h
- GSM9057414 ChIP_TAF1_3h_rep2 ChIP_TAF1_3h
- GSM9057415 ChIP_TAF1_3h_rep3 ChIP_TAF1_3h
- GSM9057416 ChIP_TAF1_3h_rep4 ChIP_TAF1_3h
- GSM9057417 ChIP_TAF1_6h_rep1 ChIP_TAF1_6h
- GSM9057418 ChIP_TAF1_6h_rep2 ChIP_TAF1_6h
- GSM9057419 ChIP_TAF1_6h_rep3 ChIP_TAF1_6h
- GSM9057420 ChIP_TAF1_6h_rep4 ChIP_TAF1_6h
- GSM9057421 ChIP_tbp_0h_rep1 ChIP_tbp_0h
- GSM9057422 ChIP_tbp_0h_rep2 ChIP_tbp_0h
- GSM9057423 ChIP_tbp_0h_rep3 ChIP_tbp_0h
- GSM9057424 ChIP_tbp_0h_rep4 ChIP_tbp_0h
- GSM9057425 ChIP_tbp_3h_rep1 ChIP_tbp_3h
- GSM9057426 ChIP_tbp_3h_rep2 ChIP_tbp_3h
- GSM9057427 ChIP_tbp_3h_rep3 ChIP_tbp_3h
- GSM9057428 ChIP_tbp_3h_rep4 ChIP_tbp_3h
- GSM9057429 ChIP_tbp_6h_rep1 ChIP_tbp_6h
- GSM9057430 ChIP_tbp_6h_rep2 ChIP_tbp_6h
- GSM9057431 ChIP_tbp_6h_rep3 ChIP_tbp_6h
- GSM9057432 ChIP_tbp_6h_rep4 ChIP_tbp_6h
- GSE254023 The TFIID subunit Taf13 is dispensable for RNA polymerase II transcription, but essential for early embryogenesis (ChIP-Seq) 12 samples shares tfiid, polymerase, chip-seq
- GSE254025 The TFIID subunit Taf13 is dispensable for RNA polymerase II transcription, but essential for early embryogenesis 24 samples shares tfiid, polymerase
- GSE47949 ChIP-seq analysis of histone modifications and RNA polymerase II at 4 stages of directed cardiac differentiation of mouse embryonic stem cells 54 samples shares polymerase, chip-seq
- GSE239564 Chromatin activity of IκBα mediates the exit from naïve pluripotency (ChIP-seq Histone marks) 38 samples shares pluripotency, chip-seq
- GSE324933 DGCR8 promotes RNA polymerase II pause release independently of DROSHA [ChIP-seq] 32 samples shares polymerase, chip-seq
- GSE253479 FoxO transcription factors actuate the formative pluripotency specific gene expression programme [ChIP-Seq] 32 samples shares pluripotency, chip-seq
- GSE269920 Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq] 30 samples shares pluripotency, chip-seq
- GSE276879 Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts 30 samples shares pluripotency, maintain
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.