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SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina

GSE268463 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/12/06 Platform GPL21273
Summary
There is a growing need to better characterise senescent cells in the CNS and retina. The recently published SenMayo gene panel was developed to identify transcriptomic signatures of senescence across multiple organ systems, but the retina was not included. While other approaches have identified senescent signatures in the retina, these have largely focused on experimental models in young animals. We therefore conducted a detailed single-cell RNA-seq analysis to identify senescent cell populations in the retina of different aged mice and compared these with five comprehensive human and mouse retina and brain transcriptome datasets. Transcriptomic signatures of senescence were most apparent in mouse and human retinal glial cells, with IL4, 13 and 10 and the AP1 pathway being the most prominent markers involved. Similar levels of transcriptional senescence were observed in the retinal glia of young and old mice, whereas the human retina showed significantly increased enrichment scores with advancing age.
Published in
SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina
Suresh S, Karthik G, Ouyang JF et al. · npj aging 2024 · PMID 39616175 · doi:10.1038/s41514-024-00187-9
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Also filed as BioProject PRJNA1117415 and SRA study SRP510279. Searching any of these in the dataset finder brings you back here.

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