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Effect of MEIS2 overexpression on HT22 cells

GSE268702 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/29 Platform GPL34290
Summary
We determined MEIS2 was notably elevated in AD models and AD patients. Alterations in the expression of MEIS2 can modulate the levels of BACE1. MEIS2 down-regulation improved the learning and memory retention of AD mice and decreased the number of amyloid plaques. MEIS2 binds to the BACE1 promoter, positively regulates BACE1 expression, and accelerates APP amyloid degradation in vitro. Therefore, our findings suggest that MEIS2 might be a critical transcription factor in AD, since it regulates BACE1 expression and accelerates BACE1-mediated APP amyloidogenic cleavage. MEIS2 is a promising early intervention target for AD treatment.
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Also filed as BioProject PRJNA1118290 and SRA study SRP510860. Searching any of these in the dataset finder brings you back here.

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